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2H-Tetrazole-2-carboxamide, 5-([1,1'-biphenyl]-4-ylmethyl)-N,N-dimethyl-

Names

[ CAS No. ]:
1010096-65-7

[ Name ]:
2H-Tetrazole-2-carboxamide, 5-([1,1'-biphenyl]-4-ylmethyl)-N,N-dimethyl-

[Synonym ]:
5-(4-Biphenylylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide
5-Biphenyl-4-yl-2-phenyl-oxazol
2H-Tetrazole-2-carboxamide, 5-([1,1'-biphenyl]-4-ylmethyl)-N,N-dimethyl-

Biological Activity

[Description]:

AM6701 is a potent FAAH/MAGL inhibitor (equipotent inhibitory IC50: 1.2 nM) with neuroprotective effects[1].

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> MAGL
Signaling Pathways >> Metabolic Enzyme/Protease >> FAAH
Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> FAAH

[Target]

IC50: 1.2 nM (FAAH/MAGL)[1]


[References]

[1]. Vinogran Naidoo, et al.Equipotent inhibition of fatty acid amide hydrolase and monoacylglycerol lipase - dual targets of the endocannabinoid system to protect against seizure pathology.Neurotherapeutics.2012 Oct;9(4):801-13.  

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
506.1±53.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H17N5O

[ Molecular Weight ]:
307.35

[ Flash Point ]:
259.9±30.9 °C

[ Exact Mass ]:
307.143311

[ PSA ]:
63.91000

[ LogP ]:
2.15

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.640

Related Compounds