Ademetionine 1,4-butanedisulfonate

Names

[ Name ]:
Ademetionine 1,4-butanedisulfonate

[Synonym ]:
S-Adenosylmethione-1,4-butanedisulfonate
Ademethionine 1,4-Butanedisulfonate
AdeMetionine 1,4-Butandisulphate
S-ADENOSYLMETHIONINE1,4-BUTANEDUSULFONATE
[(3S)-3-Amino-3-carboxypropyl]{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydro-2-furanyl]methyl}methylsulfonium 1,4-butanedisulfonate - 1,4-butanedisulfonic acid (2:1:2) (non-preferred name)
s-adenosylmethionine 1,4-butanedisulfonate
S-Adenosyl-L-methionine 1,4-butanedisulfonate sodium salt

Biological Activity

[Description]:

SAMe-1,4-Butanedisulfonate, a natural compound, is a methyl donor in the central nervous system. SAMe-1,4-Butanedisulfonate has antidepressant activity. SAMe-1,4-Butanedisulfonate can be used for research of CNS disorders[1][2][3][4].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Research Areas >> Neurological Disease

[In Vivo]

SAMe-1,4-Butanedisulfonate (30 和 60 mg/kg/天，肌肉注射) 增加实验性骨关节炎兔损伤软骨的厚度和细胞密度[2]。 SAMe-1,4-Butanedisulfonate (60 和 100 mg/kg/天，肌肉注射) 保护大鼠免受 d-半乳糖胺诱导的肝损伤[3]。 SAMe-1,4-Butanedisulfonate (10-200 mg/kg，腹腔注射) 对接受强迫游泳试验 (FST) 和悬尾试验 (TST) 的小鼠表现出抗抑郁样作用[4]。 Animal Model: Mice submitted to the forced swimming test (FST) and tail suspension test (TST)[4] Dosage: 10, 255, 50, 100, 200 mg/kg Administration: i.p. Result: Reduced the immobility time in the FST and reduced the total distance traveled.

[References]

[1]. Delle Chiaie R, et al. Efficacy and tolerability of oral and intramuscular S-adenosyl-L-methionine 1,4-butanedisulfonate (SAMe) in the treatment of major depression: comparison with imipramine in 2 multicenter studies. Am J Clin Nutr. 2002 Nov;76(5):1172S-6S.

[2]. Barceló HA, et al. Osteoartritis experimental y su evolución bajo tratamiento con S-adenosil-L-metionina (SAMe) [Experimental osteoarthritis and its course when treated with S-adenosyl-L-methionine]. Rev Clin Esp. 1990 Jun;187(2):74-8. Spanish.

[3]. Stramentinoli G, et al. Protective role of S-adenosyl-L-methionine on liver injury induced by D-galactosamine in rats. Biochem Pharmacol. 1978 May 15;27(10):1431-3.

[4]. Sales AJ, et al. S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT1A receptors. Neurochem Int. 2023 Jan;162:105442.