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Teriflunomide impurity 3

Names

[ CAS No. ]:
1011244-72-6

[ Name ]:
Teriflunomide impurity 3

[Synonym ]:
Benzamide, 4-amino-N-[4-(trifluoromethyl)phenyl]-
4-Amino-N-[4-(trifluoromethyl)phenyl]benzamide

Biological Activity

[Description]:

Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor with an IC50 of 30 µM. Teriflunomide impurity 3 is less active against COX-2 (IC50>100 µM)[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Immunology/Inflammation >> COX

[Target]

COX-1:30 μM (IC50)


[In Vitro]

Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide; compound 11q) is an amide-bond-reversed compound bearing trifluoromethyl and amino substituents showed potent COX-1-selective inhibitory activity[1].

[References]

[1]. Hiroki Kakuta, et al. Cyclooxygenase-1-selective inhibitors are attractive candidates for analgesics that do not cause gastric damage. design and in vitro/in vivo evaluation of a benzamide-type cyclooxygenase-1 selective inhibitor. J Med Chem. 2008 Apr 24;51(8):2400-11.

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
327.6±42.0 °C at 760 mmHg

[ Molecular Formula ]:
C14H11F3N2O

[ Molecular Weight ]:
280.245

[ Flash Point ]:
151.9±27.9 °C

[ Exact Mass ]:
280.082336

[ LogP ]:
2.87

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.602

[ Storage condition ]:
-20°C

Related Compounds