PTZ-343

Names

[ Name ]:
PTZ-343

[Synonym ]:
10H-Phenothiazine-10-propanesulfonic acid, sodium salt (1:1)
Sodium 3-(10H-phenothiazin-10-yl)-1-propanesulfonate
sodium,3-phenothiazin-10-ylpropane-1-sulfonate
10H-Phenothiazine-10-propanesulfonic acid,sodiumsalt(1:1)
PTZ-343
10H-Phenothiazine-10-propanesulfonicacid, sodium salt (1:1)

Biological Activity

[Description]:

PTZ-343 is a potent enhancer of Luminol (HY-15922). PTZ-343 greatly increases the light output of the peroxidase-catalyzed luminol chemiluminescent oxidation reaction (>80%)[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[In Vitro]

PTZ-343 behaves as electron transfer mediator, it reacts with HRP-II to release HRP and a enhance (PTZ-343) radical. The enhancer (PTZ-343) radical quickly oxidizes luminol anions to induce light emission[1].

[References]

[1]. Ettore Marzocchi, et al. Chemiluminescent detection systems of horseradish peroxidase employing nucleophilic acylation catalysts. Anal Biochem. 2008 Jun 15;377(2):189-94.

[2]. WenxiaZhang, et al. A novel electrochemical biomimetic sensor based on E-MIP artificial acceptor and SI-ATRP assisted signal amplification. Journal of Electroanalytical Chemistry. Volume 842, 1 June 2019, Pages 24-33

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₅H₁₄NNaO₃S₂

[ Molecular Weight ]:
343.396

[ Exact Mass ]:
343.031281

[ PSA ]:
94.12000

[ LogP ]:
4.37040

Safety Information

[ HS Code ]:
2934999090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%