<Suppliers Price>

ML-030

Names

[ CAS No. ]:
1013750-77-0

[ Name ]:
ML-030

[Synonym ]:
3-(2,5-Dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine
7H-1,2,4-Triazolo[3,4-b][1,3,4]thiadiazine, 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-
ML-030

Biological Activity

[Description]:

ML-030 is a potent PDE4 inhibitor, with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE)
Research Areas >> Inflammation/Immunology

[Target]

IC50: 6.7 nM (PDE4A), 12.9 nM (PDE4A1), 48.2 nM (PDE4B1), 37.2 (PDE4B2) nM, 452 (PDE4C1) nM, 49.2 (PDE4D2) nM[1]


[In Vitro]

ML-030 is potent in cell-based assay with an EC50 value of 18.7 nM[1].

[References]

[1]. Skoumbourdis AP, et al. Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitors. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3686-92.


[Related Small Molecules]

3-Isobutyl-1-methylxanthine | rolipram | PF-04957325 | AN-2728 | GLPG1690 | BAY-60-7550 | Icariin | Ibudilast | PF-8380 | TAK-063 | Dipyridamole | Cilostazol | GSK256066 | Cialis | Pentoxifylline

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
633.2±65.0 °C at 760 mmHg

[ Molecular Formula ]:
C20H20N4O4S

[ Molecular Weight ]:
412.462

[ Flash Point ]:
336.7±34.3 °C

[ Exact Mass ]:
412.120514

[ PSA ]:
105.29000

[ LogP ]:
3.56

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.650

[ Storage condition ]:
2-8℃

Related Compounds