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BC-1382

Names

[ CAS No. ]:
1013753-99-5

[ Name ]:
BC-1382

[Synonym ]:
4-Piperidinecarboxamide, N-[(1S)-2-[[(2-methoxyphenyl)methyl]amino]-1-methyl-2-oxoethyl]-1-(phenylsulfonyl)-
N-{(2S)-1-[(2-Methoxybenzyl)amino]-1-oxo-2-propanyl}-1-(phenylsulfonyl)-4-piperidinecarboxamide
MFCD08290616
MFCD30470656

Biological Activity

[Description]:

A potent ubiquitin E3 ligase HECTD2 inhibitor that specificly disrupts the HECTD2/PIAS1 interaction with IC50 of 5 nM; drastically increases PIAS1 protein level with IC50 of 100 nM and improves PIAS1 protein stability, with no effect on PIAS3, PIAS4, and HECTD2 protein levels; suppresses LPS-induced PIAS1 degradation and restores PIAS1 protein levels at 800 nM, and proinflammatory cytokines released by PBMCs; attenuates LPS- and Pseudomonas aeruginosa-induced lung inflammation

[References]

References 1. Coon TA, et al. Sci Transl Med. 2015 Jul 8;7(295):295ra109. View Related Products by Target E3 Ubiquitin Ligase

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Molecular Formula ]:
C23H29N3O5S

[ Molecular Weight ]:
459.559

[ Exact Mass ]:
459.182800

[ LogP ]:
2.13

[ Index of Refraction ]:
1.584

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds