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Propargyl-PEG4-amine

Names

[ CAS No. ]:
1013921-36-2

[ Name ]:
Propargyl-PEG4-amine

[Synonym ]:
3,6,9,12-Tetraoxapentadec-14-yn-1-amine

Biological Activity

[Description]:

Propargyl-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Banerjee SR, et al. 111In- and IRDye800CW-Labeled PLA-PEG Nanoparticle for Imaging Prostate-Specific MembraneAntigen-Expressing Tissues. Biomacromolecules. 2017 Jan 9;18(1):201-209.

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
315.9±32.0 °C at 760 mmHg

[ Molecular Formula ]:
C11H21NO4

[ Molecular Weight ]:
231.289

[ Flash Point ]:
141.3±18.8 °C

[ Exact Mass ]:
231.147064

[ LogP ]:
-1.18

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.462

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Related Compounds