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MLS-573151

Names

[ CAS No. ]:
10179-57-4

[ Name ]:
MLS-573151

[Synonym ]:
4-(3,5-Diphenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
1-<4-Pyrrolidinomethyl-phenyl>-2-phenyl-6-methoxy-3,4-dihydronaphthalin-hydrochlorid
Benzenesulfonamide, 4-(4,5-dihydro-3,5-diphenyl-1H-pyrazol-1-yl)-
MLS-573151

Biological Activity

[Description]:

MLS-573151 (MLS000573151) is a selective GTPase Cdc42 inhibitor with an EC50 of 2 μM. MLS-573151 is inactive against other GTPases family members, such as Rab2, Rab7, H-Ras, Rac1, Rac 2 and RhoA wild-type. MLS-573151 acts by blocking the binding of GTP to Cdc42[1][2].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Ras

[In Vitro]

The fluorescence intensities of phagocytosed beads or bacteria in hemocytes, taken as a measure of phagocytosis efficiency, were markedly reduced in granulocytes treated with MLS-573151 (50 μM; for 15 min) compared to that in the control group. MLS-573151 could effectively inhibit the phagocytic ability of granulocytes[1].

[References]

[1]. Zurab Surviladze, et al. Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay. J Biomol Screen. 2010 Jan;15(1):10-20.

[2]. Fan Mao, et al. Transcriptomic Evidence Reveals the Molecular Basis for Functional Differentiation of Hemocytes in a Marine Invertebrate, Crassostrea gigas. Front Immunol. 2020 May 27;11:911.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
596.3±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H19N3O2S

[ Molecular Weight ]:
377.460

[ Flash Point ]:
314.5±32.9 °C

[ Exact Mass ]:
377.119812

[ PSA ]:
84.14000

[ LogP ]:
1.90

[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C

[ Index of Refraction ]:
1.669

Synthetic Route

Click to get detail synthetic route

Related Compounds