Diclazuril

Names

[ Name ]:
Diclazuril

[Synonym ]:
Vecoxan
Qiujia
MFCD00867203
CLINACOX
Nuoqiu
DICLAZUTIL
clinazox

Biological Activity

[Description]:

Diclazuril is an anti-coccidial drug. Target: AntiparasiticDiclazuril is a coccidiostat, the lambs treated with diclazuril showed an intense, persistent oocyst excretion, with average levels of 97.54 opg, considerably higher than those recorded in the animals treated with toltrazuril (p < 0.05) [1]. Diclazuril is effective against E. maxima later in its life cycle, subclinical intestinal lesions may be present for a short time after infection. Diclazuril was shown in studies to reduce lesion scores and improve performance and health of birds challenged with E. maxima [2].

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Parasite

Natural Products >> Others

Research Areas >> Infection

[References]

[1]. Diaferia, M., et al., Efficacy of toltrazuril 5 % suspension (Baycox(R), Bayer) and diclazuril (Vecoxan(R), Janssen-Cilag) in the control of Eimeria spp. in lambs. Parasitol Res, 2013. 112 Suppl 1: p. 163-8.

[2]. http://www.huvepharma.com/products/view/190

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Melting Point ]:
548ºC

[ Molecular Formula ]:
C₁₇H₉Cl₃N₄O₂

[ Molecular Weight ]:
407.638

[ Exact Mass ]:
405.979095

[ PSA ]:
91.54000

[ LogP ]:
2.44

[ Index of Refraction ]:
1.702

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
R36/37/38:Irritating to eyes, respiratory system and skin .

[ Safety Phrases ]:
S26-S36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Increased level of Eimeria sensitivity to diclazuril after using a live coccidial vaccine.

Avian Dis. 50(3) , 321-4, (2006)

Anticoccidial vaccine and an anticoccidial drug rotation program were compared to determine which program was more effective in producing coccidia populations sensitive of 1 ppm diclazuril. The study ...

Comparison of three adjuvants used to produce polyclonal antibodies to veterinary drugs.

Vet. Immunol. Immunopathol. 122(1-2) , 25-34, (2008)

Two commercially available adjuvants, Gerbu LQ 3000 and Montanide ISA 50V, were assessed as potential replacements for Freund's adjuvant by evaluating their efficacy in the production of polyclonal an...

Determination of diclazuril, toltrazuril and its two metabolites in poultry tissues and eggs by gel permeation chromatography-liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 879(20) , 1757-63, (2011)

A new procedure has been described for the extraction of diclazuril (DIZ), toltrazuril (TOZ) and its two main metabolites toltrazuril sulphoxide (TZSO) and toltrazuril sulphone (TZS) from poultry tiss...