m-PEG8-CH2COOH

Names

[ CAS No. ]:
102013-72-9

[ Name ]:
m-PEG8-CH2COOH

[Synonym ]:
3,6,9,12,15,18,21,24,27-nonaoxa-octacosanoic acid
3,6,9,12,15,18,21,24,27-Nonaoxa-octacosansaeure

Biological Activity

[Description]:

m-PEG8-CH2COOH is a PEG--based PROTAC linker can be used in the synthesis of PROTACs.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Alexander Chucholowski, et al. Cyclodextrin conjugates. WO2010017328A2.

Chemical & Physical Properties

[ Density]:
1.122

[ Molecular Formula ]:
C₁₉H₃₈O₁₁

[ Molecular Weight ]:
442.49800

[ Exact Mass ]:
442.24100

[ PSA ]:
120.37000

Safety Information

[ Hazard Codes ]:
Xi

m-PEG8-CH2COOH

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds