Acetyl Coenzyme A trisodium

Names

[ CAS No. ]:
102029-73-2

[ Name ]:
Acetyl Coenzyme A trisodium

[Synonym ]:
ACETHYL COENZYME A SODIUM SALT
ACETYL COENZYME A (C2:0) SODIUMPREPARED ENZYMATICA
Adenosine, 5'-O-[[[[4-[[3-[[2-(acetylthio)ethyl]amino]-3-oxopropyl]amino]-3-hydroxy-2,2-dimethyl-4-oxobutoxy]hydroxyphosphinyl]oxy]hydroxyphosphinyl]-, 3'-(dihydrogen phosphate)
Acetyl-Coenzym A
acetyl coa
C2:0
S-{1-[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydro-2-furanyl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3λ,5λ-dipho sphaheptadecan-17-yl} ethanethioate
Acetyl Coenzyme A Trisodium Salt
coenzyme A acetyl derivative (C2:0),sodium salt
Acetyl Coenzyme A
MFCD00078858

Biological Activity

[Description]:

Acetyl Coenzyme A trisodium (Acetyl-CoA trisodium) is a central metabolic intermediate. Acetyl Coenzyme A trisodium is the actual molecule through which glycolytic pyruvate enters the tricarboxylic acid (TCA) cycle, is a key precursor of lipid synthesis, and is the sole donor of the acetyl groups for acetylation. Acetyl Coenzyme A trisodium acts as a potent allosteric activator of pyruvate carboxylase (PC)[1].

[Related Catalog]:

Research Areas >> Metabolic Disease

[In Vitro]

Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant molecule constituted by an acetyl moiety (CH3CO) linked to coenzyme A (CoA), a derivative of vitamin B5 and cysteine, through a thioester bond. As thioester bonds are energy rich, the chemical structure of acetyl-CoA facilitates the transfer of the acetyl moiety to a variety of acceptor molecules, including amino groups on proteins[1]. In most mammalian cells, Acetyl-coenzyme A (Acetyl-CoA) is predominantly generated in the mitochondrial matrix by various metabolic circuitries, namely glycolysis, β-oxidation, and the catabolism of branched amino acids. Cytosolic Acetyl-coenzyme A is the precursor of multiple anabolic reactions that underlie the synthesis of fatty acids and steroids, as well as specific amino acids including glutamate, proline, and arginine[1].

[In Vivo]

Mice deprived of food (but with access to water ad libitum) for 24 hr exhibit a significant reduction in total Acetyl-coenzyme A (Acetyl-CoA) levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl-coenzyme A concentrations in the brain and actually increase hepatic Acetyl-coenzyme A and protein acetylation levels. Ethanol intake augments Acetyl-coenzyme A levels in hepatic mitochondria[1].

[References]

[1]. Federico Pietrocola, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21.

Chemical & Physical Properties

[ Density]:
1.9±0.1 g/cm3

[ Molecular Formula ]:
C₂₃H₃₈N₇O₁₇P₃S

[ Molecular Weight ]:
809.571

[ Exact Mass ]:
809.125793

[ PSA ]:
418.36000

[ LogP ]:
-3.89

[ Index of Refraction ]:
1.718

[ Storage condition ]:
-20 °C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Risk Phrases ]:
R23/24/25

[ Safety Phrases ]:
24-36/37-45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

Articles

Direct biosynthesis of adipic acid from a synthetic pathway in recombinant Escherichia coli.

Biotechnol. Bioeng. 111(12) , 2580-6, (2014)

The C6 dicarboxylic acid, adipic acid, is an important platform chemical in industry. Biobased production of adipic acid is a promising alternative to the current petrochemical route. Here, we report ...

Role of carnitine acetyltransferases in acetyl coenzyme A metabolism in Aspergillus nidulans.

Eukaryotic Cell 10 , 547-555, (2011)

The flow of carbon metabolites between cellular compartments is an essential feature of fungal metabolism. During growth on ethanol, acetate, or fatty acids, acetyl units must enter the mitochondrion ...

K-acetylation and its enzymes: overview and new developments.

Handbook of Experimental Pharmacology 206 , 1-12, (2011)

Lysine (K) acetylation refers to transfer of the acetyl moiety from acetyl-CoA to the ε-amino group of a lysine residue. This is posttranslational and reversible, with its level dynamically maintained...