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Minoxidil-d10

Names

[ CAS No. ]:
1020718-66-4

[ Name ]:
Minoxidil-d10

[Synonym ]:
2,4-pyrimidinediamine, 6-(1-piperidinyl-d10)-, 3-oxide
6-[(2H10)-1-Piperidinyl]-2,4-pyrimidinediamine 3-oxide
6-[(2H10)Piperidin-1-yl]pyrimidine-2,4-diamine 3-oxide

Biological Activity

[Description]:

Minoxidil-d10 (U10858-d10) is the deuterium labeled Minoxidil. Minoxidil (U10858) is an ATP-sensitive potassium (KATP) channel opener, a potent oral antihypertensive agent and a peripheral vasodilator that promotes vasodilation also affects hair growth. Minoxidil is also a potent inhibitor of soybean lipoxygenaseare with an IC50 of 20 μM[1][2][3].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[In Vitro]

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

[References]

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Cox L, et al. Levomepromazine for nausea and vomiting in palliative care. Cochrane Database Syst Rev. 2015;2015(11):CD009420. Published 2015 Nov 2.

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
544.9±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C9H5D10N5O

[ Molecular Weight ]:
219.310

[ Flash Point ]:
283.4±32.9 °C

[ Exact Mass ]:
219.190430

[ LogP ]:
-0.41

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.724

Related Compounds