MAO-B-IN-16

Names

[ CAS No. ]:
1021238-13-0

[ Name ]:
MAO-B-IN-16

Biological Activity

[Description]:

MAO-B-IN-16 is a selective monoamine oxidase B (MAO-B) inhibitor, with an IC50 of 1.55 µM. MAO-B-IN-16 can be used in the study of central nervous disorders, such as parkinson's disease[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase
Research Areas >> Neurological Disease

[Target]

hMAO-B:1.55 μM (IC50)

hMAO-A:＞100 μM (IC50)


[In Vitro]

MAO-B-IN-16 (compound 4h) (10 μM; 24 h) has no cytotoxic effect on human neuroblastoma cells[1]. Cell Viability Assay[1] Cell Line: SH-SY5Y cells Concentration: 10 μM Incubation Time: 24 h Result: Showed no cytotoxic effect on cells with cellular viability of 99%.

[References]

[1]. Yamada M, et al. Design, Synthesis, and Monoamine Oxidase B Selective Inhibitory Activity of N-Arylated Heliamine Analogues. ACS Medicinal Chemistry Letters, 2022.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H19NO3

[ Molecular Weight ]:
297.35

Related Compounds