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RJR 2429 dihydrochloride

Names

[ CAS No. ]:
1021418-53-0

[ Name ]:
RJR 2429 dihydrochloride

[Synonym ]:
2-(Pyridin-3-yl)quinuclidine dihydrochloride
RJR 2429 (hydrochloride)
1-Azabicyclo[2.2.2]octane, 2-(3-pyridinyl)-, hydrochloride (1:2)
2-(3-Pyridinyl)quinuclidine dihydrochloride

Biological Activity

[Description]:

RJR 2429 hydrochloride is a α4β2 and α7 nAChR agonist[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR
Signaling Pathways >> Neuronal Signaling >> nAChR
Research Areas >> Neurological Disease

[References]

[1]. Bhatti BS, et al. Synthesis of 2-(pyridin-3-yl)-1-azabicyclo[3.2.2]nonane, 2-(pyridin-3-yl)-1-azabicyclo[2.2.2]octane, and 2-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, a class of potent nicotinic acetylcholine receptor-ligands. J Org Chem. 2008 May 2;73(9):3497-507.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H18Cl2N2

[ Molecular Weight ]:
261.191

[ Exact Mass ]:
260.084717

Related Compounds