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ARN2966

Names

[ CAS No. ]:
102212-26-0

[ Name ]:
ARN2966

[Synonym ]:
2-[(Pyridin-2-ylmethyl)-amino]-phenol
2-N-(2-pyridylmethyl)aminophenol
(2-Hydroxyphenyl)(2-pyridylmethyl)amin
2-[(pyridine-2-ylmethyl)-amino]phenol
ARN2966
2-PMAP

Biological Activity

[Description]:

ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. IC50 value: Target: AβThis potent post-transcriptional modulation of APP expression differs from other mechanisms such as inhibition of secretases. Secretase inhibitors have been pursued as disease modifying strategies by a number of pharmaceutical firms but they have encountered numerous setbacks during clinical development. ARN2966 is non toxic, orally absorbable, blood-brain-barrier penetrable, and effective in vitro and in vivo.

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Amyloid-β
Research Areas >> Neurological Disease

[References]

[1]. http://arianeurosciences.com/science.html


[Related Small Molecules]

FPS-ZM1 | Amyloid β-Protein (25-35) trifluoroacetate salt | Ginsenoside Rg3 | Geniposide | Ginsenoside Rg1 | β-Amyloid-42 | Semagacestat(LY450139) | Edonerpic maleate | Notoginsenoside R1 | Latrepirdine | Frentizole | Ginsenoside Re | Ginsenoside Rg2

Chemical & Physical Properties

[ Molecular Formula ]:
C12H12N2O

[ Molecular Weight ]:
200.23600

[ Exact Mass ]:
200.09500

[ PSA ]:
45.15000

[ LogP ]:
2.47230

[ Storage condition ]:
2-8℃

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ RIDADR ]:
NONH for all modes of transport

Related Compounds