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ATP synthase inhibitor 1

Names

[ CAS No. ]:
1023043-30-2

[ Name ]:
ATP synthase inhibitor 1

Biological Activity

[Description]:

ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F1/FO-ATP synthase complex, inhibits mitochondrial permeability transition pore (mPTP) opening, does not affect ATP levels[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease
Signaling Pathways >> Membrane Transporter/Ion Channel >> ATP Synthase

[Target]

F1/FO-ATP synthase[1]


[In Vitro]

ATP synthase inhibitor 1 (Compound 10) is a potent inhibitor of c subunit of the F1/FO-ATP synthase complex[1].

[References]

[1]. Morciano G, et al. Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction. J Med Chem. 2018 Aug 23;61(16):7131-7143.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H18ClN3O3S2

[ Molecular Weight ]:
411.93

Related Compounds