A-940894

Names

[ CAS No. ]:
1027330-82-0

[ Name ]:
A-940894

[Synonym ]:
2,4-diamino-5,6-disubstituted pyrimidine,9
UNII-8U5620H545

Biological Activity

[Description]:

A-940894 is a potent histamine H4 receptor antagonist, with Ki values of 7.6 nM (rat H4) and 71 nM (human H4). A-940894 exhibits with anti-inflammatory properties[1].

[Related Catalog]:

Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor
Research Areas >> Inflammation/Immunology
Signaling Pathways >> GPCR/G Protein >> Histamine Receptor

[Target]

Ki: 7.6 nM (rat H4), 71 nM (human H4)[1].


[References]

[1]. M I Strakhova, et al. In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. Br J Pharmacol. 2009 May;157(1):44-54.  

Chemical & Physical Properties

[ Molecular Formula ]:
C17H21N5

[ Molecular Weight ]:
295.38200

[ Exact Mass ]:
295.18000

[ PSA ]:
67.80000

[ LogP ]:
1.94800

Related Compounds