2,3-DIPHOSPHO-D-GLYCERIC ACID PENTASODIUM SALT

Names

[ Name ]:
2,3-DIPHOSPHO-D-GLYCERIC ACID PENTASODIUM SALT

[Synonym ]:
Pentasodium (2R)-2,3-bis(phosphonatooxy)propanoate
Propanoic acid, 2,3-bis(phosphonooxy)-, sodium salt, (2R)- (1:5)
2,3-diphospho-d-glyceric acid pentasodium salt

Biological Activity

[Description]:

2,3-Diphospho-D-glyceric acid pentasodium salt is a highly anionic polyphosphorus compound. 2,3-Diphospho-D-glyceric acid is present in the concave center of red blood cells, it binds hemoglobin to reduce its oxygen affinity. 2,3-Diphospho-D-glyceric acid is an endogenous, selective inhibitor of vascular calcification (VC) and significantly delays the formation of crystalline calpain particles (CPP). 2,3-Diphospho-D-glyceric acid also inhibits calcification in mouse vascular smooth muscle cell line (MOVAS) without cytotoxic effects[1].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

[References]

[1]. Kharaghani D, Kohno S, Minamizaki T, et al. 2, 3-Diphospho-D-glyceric acid inhibits calciprotein particle growth and calcification in MOVAS cells but not in MC3T3-E1 cells[J]. Colloid and Interface Science Communications, 2022, 50: 100668.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃H₃Na₅O₁₀P₂

[ Molecular Weight ]:
375.946

[ Exact Mass ]:
375.868988

[ PSA ]:
204.59000

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Polyphosphates and pyrophosphates of hexopyranoses as allosteric effectors of human hemoglobin: synthesis, molecular recognition, and effect on oxygen release.

ChemMedChem 6(1) , 153-68, (2011)

Polyphosphorylated and perphosphorylated hexopyranose monosaccharides and disaccharides were synthesized from parent or partially protected carbohydrates as potential allosteric effectors of hemoglobi...

Development of a bifunctional filter for prion protein and leukoreduction of red blood cell components.

Transfusion 55(2) , 330-6, (2015)

Leukofiltration of blood components is currently implemented worldwide as a precautionary measure against white blood cell-associated adverse effects and the potential transmission of variant Creutzfe...

Red blood cell in vitro quality and function is maintained after S-303 pathogen inactivation treatment.

Transfusion 54(7) , 1798-807, (2014)

Over the past decade there has been a growth in the development of pathogen reduction technologies to protect the blood supply from emerging pathogens. This development has proven to be difficult for ...