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Tos-PEG7-OH

Names

[ CAS No. ]:
1028089-05-5

[ Name ]:
Tos-PEG7-OH

[Synonym ]:
MFCD24539472
2,5,8,11,14,17,20-Heptaoxadocosan-22-ol, benzenesulfonate
2,5,8,11,14,17,20-Heptaoxadocosan-22-yl benzenesulfonate

Biological Activity

[Description]:

Tos-PEG7-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
554.5±50.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H36O10S

[ Molecular Weight ]:
480.569

[ Flash Point ]:
289.1±30.1 °C

[ Exact Mass ]:
480.202911

[ LogP ]:
-1.30

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.488

Related Compounds