Inositol 1,3,4,5-tetraphosphate

Names

[ Name ]:
Inositol 1,3,4,5-tetraphosphate

[Synonym ]:
myo-inositol 1,3,4,5-tetrakisphosphate
INOSITOLTETRAPHOSPHATE
inositol-1,3,4,5-tetrakisphosphate
MYO-INOSITOL 1,3,4,6-TETRAKIS-PHOSPHATE AMMONIUM SALT
IP4
InsP4
D-myo-Inositol 1,3,4,5-tetrakisphosphoric acid
D-MYO-INOSITOL 1,3,4,5-TETRAKIS-*PHOSPHA TE AMMONIUM
Inositol 1,3,4,5-tetrakishosphate

Biological Activity

[Description]:

Inositol 1,3,4,5-tetraphosphate is the head group of PIP3 (phosphatidylinositol 3,4,5-trisphosphate)[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Liu J, et al. Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation. J Biol Chem. 2011;286(50):43334-43342.

Chemical & Physical Properties

[ Density]:
2.32 g/cm3

[ Boiling Point ]:
1015.6ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₁₆O₁₈P₄

[ Molecular Weight ]:
517.10600

[ Flash Point ]:
568ºC

[ Exact Mass ]:
516.95500

[ PSA ]:
349.98000

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.632

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

IP3 3-kinase B controls hematopoietic stem cell homeostasis and prevents lethal hematopoietic failure in mice.

Blood 125 , 2786-97, (2015)

Tight regulation of hematopoietic stem cell (HSC) homeostasis ensures lifelong hematopoiesis and prevents blood cancers. The mechanisms balancing HSC quiescence with expansion and differentiation into...

Cell signaling. The art of the soluble.

Science 316(5826) , 845-6, (2007)

Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns(3,4,5)P3 and Ins(1,3,4,5)P4, with stereospecificity.

J. Neurochem. 98(2) , 343-54, (2006)

The brain-specific protein p42IP4, also called centaurin-alpha1, specifically binds phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] and inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4]. ...