A1AR antagonist 5

Names

[ CAS No. ]:
1030509-01-3

[ Name ]:
A1AR antagonist 5

Biological Activity

[Description]:

A1AR antagonist 5 (compound 20) is a potent and selective A1AR (A1 adenosine receptor) antagonist, with a pIC50 of 5.83 and a pKi of 6.11[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

[Target]

hA1AR:6.11 (pKi)

hA2AAR:<4 (pKi)

[References]

[1]. Wei Y, et al. Identification of new potent A1 adenosine receptor antagonists using a multistage virtual screening approach. Eur J Med Chem. 2020 Feb 1;187:111936.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₁₅ClN₄O

[ Molecular Weight ]:
326.78

Related Compounds