Galactitol,1,6-dibromo-1,6-dideoxy-
Names
[ CAS No. ]:
10318-26-0
[ Name ]:
Galactitol,1,6-dibromo-1,6-dideoxy-
[Synonym ]:
1,6-Dibromodulcitol
1,6-Dibrom-1,6-didesoxy-galactit
Mitolactol
Dibromdulcitol
Dibromdulcit
1,6-Dibrom-galacto-hexan-2,3,4,5-tetraol
1,6-Dibromodideoxydulcitol
1,6-dibromo-1,6-dideoxygalactitol
dibromodulcitol
Elobromol
Chemical & Physical Properties
[ Density]:
2.117g/cm3
[ Boiling Point ]:
511.2ºC at 760mmHg
[ Melting Point ]:
183-185ºC
[ Molecular Formula ]:
C6H12Br2O4
[ Molecular Weight ]:
307.96500
[ Flash Point ]:
263ºC
[ Exact Mass ]:
305.91000
[ PSA ]:
80.92000
[ Vapour Pressure ]:
1.37E-12mmHg at 25°C
[ Index of Refraction ]:
1.622
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- LW5425000
- CHEMICAL NAME :
- Galactitol, 1,6-dibromo-1,6-dideoxy-
- CAS REGISTRY NUMBER :
- 10318-26-0
- LAST UPDATED :
- 199512
- DATA ITEMS CITED :
- 20
- MOLECULAR FORMULA :
- C6-H12-Br2-O4
- MOLECULAR WEIGHT :
- 308.00
- WISWESSER LINE NOTATION :
- E1YQYQYQYQ1E
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 72 mg/kg/D
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 470 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1238 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 550 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - protects against induction of experimental tumors
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - species unspecified
- DOSE/DURATION :
- 700 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - active as anti-cancer agent
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5850 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3500 mg/kg/26W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
- TYPE OF TEST :
- DNA adduct
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
MUTATION DATA
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Rodent - rabbit Bone marrow
- DOSE/DURATION :
- 390 umol/L
- REFERENCE :
- BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 25,1705,1976