sodium,[5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl hydrogen phosphate

Names

[ Name ]:
sodium,[5-(5-fluoro-2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl hydrogen phosphate

[Synonym ]:
FdUMP
5-Fluoro-2 inverted exclamation marka-deoxyuridine 5 inverted exclamation marka-monophosphate sodium salt
5-Fluoro-2`-deoxyuridine 5`-Monophosphate Disodium Salt
disodium 5-fluoro-2'-deoxyuridylate

Chemical & Physical Properties

[ Molecular Formula ]:
C₉H₁₁FN₂NaO₈P

[ Molecular Weight ]:
348.15400

[ Exact Mass ]:
348.01300

[ PSA ]:
163.98000

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332-H351

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
20/21/22-40

[ Safety Phrases ]:
22-36/37/39

[ RIDADR ]:
NONH for all modes of transport

Articles

Dynamic modulation of thymidylate synthase gene expression and fluorouracil sensitivity in human colorectal cancer cells.

PLoS ONE 10(4) , e0123076, (2015)

Biomarkers have revolutionized cancer chemotherapy. However, many biomarker candidates are still in debate. In addition to clinical studies, a priori experimental approaches are needed. Thymidylate sy...

Structures of human thymidylate synthase R163K with dUMP, FdUMP and glutathione show asymmetric ligand binding.

Acta Crystallogr. D Biol. Crystallogr. 67 , 60-66, (2011)

Thymidylate synthase (TS) is a well validated target in cancer chemotherapy. Here, a new crystal form of the R163K variant of human TS (hTS) with five subunits per asymmetric part of the unit cell, al...

Novel chemical strategies for thymidylate synthase inhibition.

Curr. Med. Chem. 12 , 191-202, (2005)

Thymidylate synthase (TS) is a well-validated target for cancer chemotherapy. TS was established as the principal target of the widely used anticancer drug 5-fluorouracil (5FU). The 5FU metabolite FdU...