3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile
Names
[ CAS No. ]:
1034474-19-5
[ Name ]:
3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile
Biological Activity
[Description]:
MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity for the study of viral infections.
[In Vitro]
MK-6186 showed FCs of <10 against EFV or etravirine (ETR) and the mutant viruses containing mutations selected by EFV or ETR were sensitive to MK-6186 (FCs of <10).[1]
[References]
1. Lu M, et al. Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2012 Jun;56(6):3324-35.
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
656.4±55.0 °C at 760 mmHg
[ Molecular Formula ]:
C21H12Cl2N6O
[ Molecular Weight ]:
435.266
[ Flash Point ]:
350.8±31.5 °C
[ Exact Mass ]:
434.044952
[ PSA ]:
92.41000
[ LogP ]:
4.86
[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C
[ Index of Refraction ]:
1.763