3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile

Names

[ Name ]:
3-(1-((1H-pyrazolo[3,4-b]pyridin-3-yl)Methyl)-5-chloro-1H-indazol-4-yloxy)-5-chlorobenzonitrile

Biological Activity

[Description]:

MK-6186 is a novel non-nucleoside reverse transcriptase inhibitor with antiviral activity for the study of viral infections.

[In Vitro]

MK-6186 showed FCs of <10 against EFV or etravirine (ETR) and the mutant viruses containing mutations selected by EFV or ETR were sensitive to MK-6186 (FCs of <10).[1]

[References]

1. Lu M, et al. Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor. Antimicrob Agents Chemother. 2012 Jun;56(6):3324-35.

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
656.4±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C₂₁H₁₂Cl₂N₆O

[ Molecular Weight ]:
435.266

[ Flash Point ]:
350.8±31.5 °C

[ Exact Mass ]:
434.044952

[ PSA ]:
92.41000

[ LogP ]:
4.86

[ Vapour Pressure ]:
0.0±2.0 mmHg at 25°C

[ Index of Refraction ]:
1.763