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Tetrapeptide-30

Names

[ CAS No. ]:
1036207-61-0

[ Name ]:
Tetrapeptide-30

Biological Activity

[Description]:

Tetrapeptide-30 is a skin-brightening peptide consisting of four amino acids. Tetrapeptide-30 can act as a tyrosinase inhibitor, lightening hyperpigmentation and evening out skin tone by reducing the amount of tyrosinase and inhibiting melanocyte activation[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase

[In Vitro]

Tetrapeptide-30 (0-10 μg/mL, 24 h) can effectively reduce UVB-induced gene expression of IL-6, TNF-α and POMC (proopiomelanocorticotropin), and also decreased IL-8 gene expression in a dose-dependent manner[1]. Tetrapeptide-30 (PKEK) is highly hydrophilic and has good skin penetration in microemulsion[2].

[References]

[1]. Alessandra Marini, et al. Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects. Exp Dermatol. 2012 Feb;21(2):140-6.

[2]. Reinhard H H Neubert, et al. Dermal peptide delivery using enhancer moleculs and colloidal carrier systems. Part II: Tetrapeptide PKEK. Eur J Pharm Biopharm. 2018 Mar;124:28-33.

Chemical & Physical Properties

[ Density]:
1.256±0.06 g/cm3(Predicted)

[ Boiling Point ]:
931.5±65.0 °C(Predicted)

[ Molecular Formula ]:
C22H40N6O7

[ Molecular Weight ]:
500.596

Related Compounds