tert-butyl N,N-bis(2-hydroxyethyl)carbamate

Names

[ Name ]:
tert-butyl N,N-bis(2-hydroxyethyl)carbamate

[Synonym ]:
MFCD01862953
N-Boc-diethanolamine
tert-Butyl bis(2-hydroxyethyl)carbamate
TERT-BUTYL N,N-BIS(2-HYDROXYETHYL)CARBAMATE

Biological Activity

[Description]:

N-Boc-diethanolamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker

[Target]

Cleavable

[In Vitro]

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Philip Stewart Low, et al. Small molecule ligand-targeted drug conjugates for anti-influenza chemotherapy and immunotherapy. WO2020023323A1

Chemical & Physical Properties

[ Density]:
1.085

[ Boiling Point ]:
324.2ºC at 760 mmHg

[ Molecular Formula ]:
C₉H₁₉NO₄

[ Molecular Weight ]:
205.25100

[ Flash Point ]:
149.9ºC

[ Exact Mass ]:
205.13100

[ PSA ]:
70.00000

[ LogP ]:
0.20810

[ Appearance of Characters ]:
Liquid or Oil | Colorless

[ Vapour Pressure ]:
1.95E-05mmHg at 25°C

[ Index of Refraction ]:
1.46

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Synthesis and antiviral activity of novel aza-acyclonucleosides.

Nucleosides Nucleotides 18 , 227, (1999)

We have prepared a series of novel aza-acyclonucleosides as potential antiviral agents. These compounds were prepared from diethanolamine and the desired purine or pyrimidine base via a Mitsunobu coup...

I. Solodin, T.D. Heath

Synlett , 617, (1996)

J.M. Orban et al.

J. Polym. Sci. A Polym. Chem. 37 , 3441, (1999)