Atipamezole hydrochloride

Names

[ Name ]:
Atipamezole hydrochloride

[Synonym ]:
5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazole hydrochloride
1H-Imidazole, 5-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-, hydrochloride (1:1)
Atipamezole hydrochloride
4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride (1:1)
1H-Imidazole,4-(2-ethyl-2,3-dihydro-1H-inden-2-yl)-,monohydrochloride
4-(2-Ethyl-2,3-dihydro-1H-inden-2-yl)-1H-imidazole hydrochloride
4-(2-Ethyl-2-indanyl)imidazole hydrochloride
Atipamezole HCL
5-(2-Ethyl-2,3-dihydro-1H-indene-2-yl)-1H-imidazolehydrochloride
Atipamezole (hydrochloride)

Biological Activity

[Description]:

Atipamezole hydrochloride is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Research Areas >> Neurological Disease

[Target]

Ki: 1.6 nM[1]

[In Vitro]

The affinity of atipamezole for α2-adrenoceptors and its α2/α1 selectivity ratio are considerably higher than yohimbine. Atipamezole is not selective for subtypes of α2-adrenoceptors. It has negligible affinity for 5-HT1, 5-HT2 and I2 bindings sites[1].

[In Vivo]

Atipamezole is well tolerated in rodents. In anesthetized, normotensive rats, the cardiovascular effects of atipamezole (0.01–1 mg/kg, i.v.) are rather modest. Atipamezole is commonly used by veterinarians to awaken animals from sedation or anesthesia. Atipamezole increases sexual activity in rats and monkeys. In animals with sustained nociception, atipamezole increases pain-related responses by blocking the noradrenergic feedback inhibition of pain. Atipamezole at low doses has beneficial effects on alertness, selective attention, planning, learning, and recall in experimental animals, but not necessarily on short-term working memory[1].

[References]

[1]. Pertovaara A, et al.Pharmacological properties, central nervous system effects, and potential therapeutic applicationsof atipamezole, a selective alpha2-adrenoceptor antagonist. CNS Drug Rev. 2005 Autumn;11(3):273-88.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.115g/cm3

[ Boiling Point ]:
367.1ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₁₇ClN₂

[ Molecular Weight ]:
248.751

[ Flash Point ]:
178ºC

[ Exact Mass ]:
248.108032

[ PSA ]:
28.68000

[ LogP ]:
3.65830

[ Vapour Pressure ]:
1.17E-06mmHg at 25°C

[ Storage condition ]:
Desiccate at RT

Safety Information

[ HS Code ]:
2933290090

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%