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Phellodendrine chloride

Names

[ CAS No. ]:
104112-82-5

[ Name ]:
Phellodendrine chloride

[Synonym ]:
6H-Dibenzo[a,g]quinolizinium, 5,8,13,13a-tetrahydro-2,11-dihydroxy-3,10-dimethoxy-7-methyl-, chloride, (13aS)- (1:1)
(13aS)-2,11-Dihydroxy-3,10-dimethoxy-7-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolinium chloride

Biological Activity

[Description]:

Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Others >> Others

[References]

[1]. Thu PM, et al. Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis. Eur J Pharmacol. 2019 May 5;850:23-34.

Chemical & Physical Properties

[ Melting Point ]:
249-251℃ (methanol )

[ Molecular Formula ]:
C20H24ClNO4

[ Molecular Weight ]:
377.862

[ Exact Mass ]:
377.139374

[ PSA ]:
58.92000

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DR9848050
CHEMICAL NAME :
13a-alpha-Berbinium, 2,11-dihydroxy-3,10-dimethoxy-7-methyl-, chloride
CAS REGISTRY NUMBER :
104112-82-5
LAST UPDATED :
198909
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C20-H24-N-O4.Cl
MOLECULAR WEIGHT :
377.90

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
69500 ug/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 58,138,1962

Safety Information

[ Safety Phrases ]:
24/25


Related Compounds