Kazinol F

Names

[ CAS No. ]:
104494-35-1

[ Name ]:
Kazinol F

[Synonym ]:
Kazinol F

Biological Activity

[Description]:

Kazinol F is a polyphenol from Broussonetia papyrifera. Kazinol F also is an effective Mpro inhibitor. Kazinol F has interaction with both the catalytic residues (His41 and Cys145) of Mpro and exhibits good binding affinity. Kazinol F can be used for the research of COVID-19[1].

[Related Catalog]:

Research Areas >> Infection
Signaling Pathways >> Anti-infection >> SARS-CoV
Research Areas >> Inflammation/Immunology

[In Vitro]

Kazinol F 与 Mpro 的催化残基（His41 和 Cys145）相互作用，并表现出良好的结合亲和力 (-8.1kcal/mol)[1]。

[References]

[1]. Ghosh, Rajesh et al. Identification of polyphenols from Broussonetia papyrifera as SARS CoV-2 main protease inhibitors using in silico docking and molecular dynamics simulation approaches. J Biomol Struct Dyn. vol. 39,17 (2021): 6747-6760.  

Chemical & Physical Properties

[ Density]:
1.15g/cm3

[ Boiling Point ]:
590ºC at 760mmHg

[ Molecular Formula ]:
C25H32O4

[ Molecular Weight ]:
396.51900

[ Flash Point ]:
258.9ºC

[ Exact Mass ]:
396.23000

[ PSA ]:
80.92000

[ LogP ]:
5.70170

[ Vapour Pressure ]:
1.61E-14mmHg at 25°C

[ Index of Refraction ]:
1.607

Related Compounds