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m-PEG7-Br

Names

[ CAS No. ]:
104518-25-4

[ Name ]:
m-PEG7-Br

[Synonym ]:
1-{2-[2-(2-Bromo-ethoxy)-ethoxy]-ethoxy}-2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethane
m-PEG-7-Br
mPEG7-Br
m-PEG-7-bromide

Biological Activity

[Description]:

m-PEG7-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C15H31BrO7

[ Molecular Weight ]:
403.30600

[ Exact Mass ]:
402.12500

[ PSA ]:
64.61000

[ LogP ]:
1.12730

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds