Ambrisentan-d10

Names

[ Name ]:
Ambrisentan-d10

[Synonym ]:
Ambrisentan-d10

Biological Activity

[Description]:

Ambrisentan-d10 (BSF 208075-d10; LU 208075-d10) is the deuterium labled Ambrisentan (HY-13209). Ambrisentan is a selective ET type A receptor (ETAR) antagonist.

[Related Catalog]:

Research Areas >> Cardiovascular Disease

[References]

[1]. Okamoto T, et al. Antifibrotic effects of Ambrisentan, an endothelin-A receptor antagonist, in a non-alcoholic steatohepatitis mouse model. World J Hepatol. 2016 Aug 8;8(22):933-41.

[2]. Lisk C, et al. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness. Free Radic Biol Med. 2013 Oct;63:264-73.

[3]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Chemical & Physical Properties

[ Melting Point ]:
>160°C

[ Molecular Formula ]:
C₂₂H₁₂D₁₀N₂O₄

[ Molecular Weight ]:
388.48

[ Exact Mass ]:
388.22100

[ PSA ]:
81.54000

[ LogP ]:
3.51560

[ Storage condition ]:
-20C

Ambrisentan-d10

Names

Biological Activity

Chemical & Physical Properties

Related Compounds