STA 2842

STA 2842 (STA2842) is a highly specific inhibitor of HSP90 (IC50=135 nM, HSP90α) that competitively binds the N-terminal ATP pocket of HSP90; induces the degradation of many ADPKD-relevant HSP90 client proteins in Pkd1(-/-) primary kidney cells and in vivo; significantly reduces initial formation of renal cysts and kidney growth and slows the progression of these phenotypes in mice with preexisting cysts.

References 1. Seeger-Nukpezah T, et al. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12786-91. 2. Nikonova AS, et al. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12859-64. 3. Smithline ZB, et al. PLoS One. 2014 Dec 4;9(12):e114403. View Related Products by Target Heat Shock Protein (HSP)