GppCp(GMPPCP)

Names

[ Name ]:
GppCp(GMPPCP)

[Synonym ]:
GMPPCP
[[[5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]methylphosphonic acid,sodium
trisodium guanosine 5'-[beta,gamma-methylene]triphosphate
GppCp
|A,|A-Methyleneguanosine 5 inverted exclamation marka-triphosphate sodium salt

Biological Activity

[Description]:

5′-Guanylyl methylenediphosphonate (sodium) is a GTP analogue and a specific, competitive inhibitor of the GTP reaction in protein synthesis[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Hershey JW, et.al. A competitive inhibitor of the GTP reaction in protein synthesis. J Mol Biol. 1966 Jun;18(1):68-76.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₁H₁₅N₅Na₃O₁₃P₃

[ Molecular Weight ]:
587.15

[ Exact Mass ]:
544.00100

[ PSA ]:
320.29000

MSDS

Click to get detail MSDS

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

Articles

Polarized endosome dynamics by spindle asymmetry during asymmetric cell division.

Nature 528 , 280-5, (2015)

During asymmetric division, fate determinants at the cell cortex segregate unequally into the two daughter cells. It has recently been shown that Sara (Smad anchor for receptor activation) signalling ...

Dynamic and thermodynamic response of the Ras protein Cdc42Hs upon association with the effector domain of PAK3.

J. Mol. Biol. 426(21) , 3520-38, (2014)

Human cell division cycle protein 42 (Cdc42Hs) is a small, Rho-type guanosine triphosphatase involved in multiple cellular processes through its interactions with downstream effectors. The binding dom...

Regulation of human tissue transglutaminase function by magnesium-nucleotide complexes. Identification of distinct binding sites for Mg-GTP and Mg-ATP.

J. Biol. Chem. 273 , 1776-1781, (1998)

Tissue transglutaminase (tTG) catalyzes a Ca(2+)-dependent transglutaminase (TGase) activity that stabilizes tissues and a GTP hydrolysis activity that regulates cell receptor signaling. The purpose o...