Methylmalonyl coenzyme A tetralithium

Names

[ Name ]:
Methylmalonyl coenzyme A tetralithium

[Synonym ]:
(2R)-3-[2-[3-[[4-[[[5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonatooxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-2-methyl-3-oxopropanoate

Biological Activity

[Description]:

Methylmalonyl coenzyme A (Methylmalonyl-CoA) tetralithium is a catabolite of valine, isoleucine, methionine, threonine, odd-chain fatty acids, and cholesterol. Methylmalonyl coenzyme A is converted to succinyl-CoA by enzymatic reaction of methylmalonyl-CoA mutase (MCM) with coenzyme vitamin B12[1].

[Related Catalog]:

Research Areas >> Others

[References]

[1]. Gotoh K, et al. Assay for methylmalonyl coenzyme A mutase activity based on determination of succinyl coenzyme A by ultrahigh-performance liquid chromatography tandem mass spectrometry. Anal Bioanal Chem. 2015 Jul;407(18):5281-6.

Chemical & Physical Properties

[ Density]:
1.92g/cm3

[ Molecular Formula ]:
C₂₅H₃₆Li₄N₇O₁₉P₃S

[ Molecular Weight ]:
891.34

[ Exact Mass ]:
867.13100

[ PSA ]:
462.64000

[ LogP ]:
0.64720

[ Index of Refraction ]:
1.72

[ Storage condition ]:
20°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
22-26-36

[ RIDADR ]:
NONH for all modes of transport

Articles

Adenosyltransferase tailors and delivers coenzyme B12.

Nat. Chem. Biol. 4 , 194-196, (2008)

The reactivity and relative rarity of most cofactors pose challenges for their delivery to target enzymes. Using kinetic analyses, we demonstrate that adenosyltransferase, which catalyzes the final st...

IcmF is a fusion between the radical B12 enzyme isobutyryl-CoA mutase and its G-protein chaperone.

J. Biol. Chem. 285 , 655-666, (2010)

Coenzyme B(12) is used by two highly similar radical enzymes, which catalyze carbon skeleton rearrangements, methylmalonyl-CoA mutase and isobutyryl-CoA mutase (ICM). ICM catalyzes the reversible inte...

CE assay of methylmalonyl-coenzyme-a mutase activity.

Electrophoresis 28 , 1921-1925, (2007)

Methylmalonyl-coenzyme A mutase (MCM) is a 5'-deoxyadenosylcobalamin-linked mitochondrial enzyme that catalyzes the isomerization of L-methylmalonyl-coenzyme A to succinyl-coenzyme A. We described a m...