H-Tyr-Tyr-OH

H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme (ACE) with an IC50 value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure[1][2].

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Metabolic Enzyme/Protease >> Angiotensin-converting Enzyme (ACE)

IC50: 0.028 mg/mL (ACE)[2]

H-Tyr-Tyr-OH shows inhibitory effect against ACE with an IC50 value of 0.028 mg/mL[2].

H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo[1]. H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats[1]. Animal Model: Anesthetized male SpragueDawley rats[1] Dosage: 12.5 mg/kg Administration: Intraarterial injection; 12.5 mg/kg once Result: Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration. Animal Model: Spontaneously hypertensive rats[1] Dosage: 0, 50 and 100 mg/kg Administration: Intraperitoneal injection; once Result: Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg.

[1]. Maher TJ, et al. Use of parenteral dipeptides to increase serum tyrosine levels and to enhance catecholamine-mediated neurotransmission. J Pharm Sci. 1990 Aug;79(8):685-7.

[2]. Maruyama, et al. Purification and identification of angiotensin I-converting enzyme inhibitory peptides from Royal Jelly treated with protease. Nippon Shokuhin Kagaku Kogaku Kaishi. 2003.