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Boc-NH-PEG8-CH2CH2NH2

Names

[ CAS No. ]:
1052207-59-6

[ Name ]:
Boc-NH-PEG8-CH2CH2NH2

[Synonym ]:
MFCD31656919

Biological Activity

[Description]:

Boc-NH-PEG8-CH2CH2NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C23H48N2O10

[ Molecular Weight ]:
512.63

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds