Propargyl-PEG3-phosphonic acid ethyl ester

Names

[ CAS No. ]:
1052678-30-4

[ Name ]:
Propargyl-PEG3-phosphonic acid ethyl ester

Biological Activity

[Description]:

Propargyl-PEG3-phosphonic acid diethyl ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

[References]

[1]. Thorsten Heidelberg, et al. Oligo-ethylene glycol based phosphonate surface modification reagents and use thereof. WO2015065168A1

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₃H₂₅O₆P

[ Molecular Weight ]:
308.31

[ Storage condition ]:
-20°C

Propargyl-PEG3-phosphonic acid ethyl ester

Names

Biological Activity

Chemical & Physical Properties

Related Compounds