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Dopamine D2 receptor antagonist-1

Names

[ CAS No. ]:
1055411-77-2

[ Name ]:
Dopamine D2 receptor antagonist-1

Biological Activity

[Description]:

Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[Target]

D2R[1]

[References]

[1]. Fyfe TJ, et al. Subtle modifications to a thieno[2,3-d]pyrimidine scaffold yield negative allosteric modulators and agonists of the dopamine D2 receptor. Eur J Med Chem. 2019 Apr 15;168:474-490.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₇N₃S

[ Molecular Weight ]:
259.37

Related Compounds