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N3-PEG3-CH2CH2COOH

Names

[ CAS No. ]:
1056024-94-2

[ Name ]:
N3-PEG3-CH2CH2COOH

[Synonym ]:
Propanoic acid, 3-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]-
3-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}propanoic acid

Biological Activity

[Description]:

N3-PEG3-CH2CH2COOH a PEG-based PROTAC linker can be used in the synthesis of BI-3663 (HY-111546), BI-4216 and BI-0319. Azido-PEG3-acid is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Research Areas >> Inflammation/Immunology
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Non-cleavable


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[References]

[1]. Popow J, et al. Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions. J Med Chem. 2019 Mar 14;62(5):2508-2520.

Chemical & Physical Properties

[ Molecular Formula ]:
C9H17N3O5

[ Molecular Weight ]:
247.248

[ Exact Mass ]:
247.116821

[ LogP ]:
-0.71

Related Compounds