KS370G

KS370G is an orally active hypoglycemic and cardiovascular protective agent. KS370G improves left ventricular hypertrophy and function in pressure-overload mice heart. KS370G reduces renal obstructive nephropathy[1][2].

Research Areas >> Cardiovascular Disease

Signaling Pathways >> Others >> Others

KS370G (1 mg/kg; oral; once daily for 8 weeks) 通过降低压力过载小鼠心脏 ERK、AKT 和 GSK3β 的磷酸化，改善左心室功能，抑制心脏肥厚[1]。 KS370G (10 mg/kg; oral; once daily for 13 days) 通过减少小鼠炎症和氧化应激减轻单侧输尿管梗阻引起的肾纤维化[2]。 Animal Model: Pressure-overload ICR mice model[1] Dosage: 1 mg/kg Administration: Oral gavage, once daily for 8 weeks Result: Inhibited cardiac hypertrophy and improved cardiac function induced by pressure overload. Decreased the plasma levels of atrial natriuretic peptide and lactate dehydrogenase. Significantly reduced pressure overload-induced increase of α-SMA and phosphorylation of ERK, AKT and GSK3β. Reduced cardiac collagen accumulation. Animal Model: Male ICR mice, unilateral ureteral obstruction (UUO) model[2] Dosage: 10 mg/kg Administration: Oral, once daily for 13 days Result: Significantly attenuated collagen deposition in the obstructed kidney and inhibited UUO-induced renal fibrosis markers expression, including fibronectin, type I collagen, vimentin, and α-smooth muscle actin (α-SMA). Significantly lowered the expression of renalinflammatory chemokines/adhesion molecules and monocyte cells marker (MCP-1, VCAM-1, ICAM-1 and CD11b). Reduced renal malondialdehyde levels and reversed the expression of renal antioxidant enzymes (SOD and catalase) after UUO. Significantly inhibited UUOinduced elevated plasma AngII and TGF-β1 levels, TGF-β1 protein expression and Smad3 phosphorylation.

[1]. Weng YC, et al. KS370G, a synthetic caffeamide derivative, improves left ventricular hypertrophy and function in pressure-overload mice heart. Eur J Pharmacol. 2012 Jun 5;684(1-3):108-15.  

[2]. Chuang ST, et al. KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice. Eur J Pharmacol. 2015 Mar 5;750:1-7.