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MK6-83

Names

[ CAS No. ]:
1062271-24-2

[ Name ]:
MK6-83

[Synonym ]:
2-Thiophenesulfonamide, 5-methyl-N-[2-(1-piperidinyl)phenyl]-
5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide

Biological Activity

[Description]:

MK6-83 is a new candidate agonist of TRPML1 with an improved efficacy and potency. MK6-83 has the potential for Mucolipidosis type IV study[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel
Research Areas >> Metabolic Disease

[In Vitro]

MK6-83 2 ranging from 0.2 to 30 μM shows no signs of cytotoxicity[1]. MK6-83 appears to be significantly more efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells than on those isolated from TRPML1-/- cells[1]. Cell Viability Assay[1]. Cell Line: Lysosomes isolated from fibroblast cell lines derived from MLIV patients carrying either the F408D, the R403C or the V446L mutation[1]. Concentration: 0-10 μM. Incubation Time: 24 h. Result: Efficacious on fibroblast lysosomes isolated from R403C or V446L expressing cells. Had no significant effect on lysosomes isolated from TRPML1-/- fibroblasts.

[References]

[1]. Cheng-Chang Chen, et al. A Small Molecule Restores Function to TRPML1 Mutant Isoforms Responsible for Mucolipidosis Type IV. Nat Commun. 2014 Aug 14;5:4681.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
502.6±60.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H20N2O2S2

[ Molecular Weight ]:
336.472

[ Flash Point ]:
257.8±32.9 °C

[ Exact Mass ]:
336.096619

[ LogP ]:
3.40

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.633

[ Storage condition ]:
-20°C

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Related Compounds