NS13001
Names
[ CAS No. ]:
1062592-30-6
[ Name ]:
NS13001
Biological Activity
[Description]:
A potent, selective, allosteric and orally acitve positive modulator of small-conductance calcium-activated K+ channel KCa2.2 and KCa2.3 with EC50 of 1.6 and 0.14 uM, respectively; shows no activating effect on hSK1 or hIK channels (EC50>10 uM), and exerts less off-target effects; alleviates behavioral and neuropathological phenotypes of aging spinocerebellar ataxia type 2 (SCA2) transgenic mice.
[References]
References 1. Kasumu AW, et al. Chem Biol. 2012 Oct 26;19(10):1340-53. 2. Coleman N, et al. Mol Pharmacol. 2014 Sep;86(3):342-57. View Related Products by Target Potassium Channel
Chemical & Physical Properties
[ Molecular Formula ]:
C16H14ClN7
[ Molecular Weight ]:
339.787