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NS13001

Names

[ CAS No. ]:
1063331-94-1

[ Name ]:
NS13001

[Synonym ]:
(4-chlorophenyl)-[2-(3,5-dimethylpyrazol-1-yl)-9-methyl-9H-purin-6-yl]amine
NS13001
(4-chloro-phenyl)-[2-(3,5-dimethyl-pyrazol-1-yl)-9-methyl-9H-purin-6-yl]amine
N-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-9-methyl-9H-purin-6-amine

Biological Activity

[Description]:

NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s are 1.8 and 0.14 μM for SK2 and SK3, respectively. NS13001 holds promise as a potential therapeutic agent for treatment of spinocerebellar ataxia type 2 (SCA2) and possibly other cerebellar ataxias[1].

[Target]

EC50: 1.8 μM (SK2), 0.14 μM (SK3)[1]


[References]

[1]. Kasumu AW, et al. Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem Biol. 2012 Oct 26;19(10):1340-53.

Chemical & Physical Properties

[ Molecular Formula ]:
C17H16ClN7

[ Molecular Weight ]:
353.80900

[ Exact Mass ]:
353.11600

[ PSA ]:
73.45000

[ LogP ]:
3.63580

Related Compounds