ω-Conotoxin GVIA trifluoroacetate salt

Names

[ Name ]:
ω-Conotoxin GVIA trifluoroacetate salt

[Synonym ]:
w-ConotoxinGVIA
w-Conotoxin GVIA,Conus geographus
o-Conotoxin GVIA
MFCD00076620
M.W. 3037.35 C120H182N38O43S6

Biological Activity

[Description]:

ω-Conotoxin GVIA is an inhibitor of the N-type Ca2+ channel[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel

Research Areas >> Neurological Disease

[In Vitro]

ω-conotoxin GVIA (50 nM, 50 nL) inhibits the effects of urotensin II (UII)[1].

[References]

[1]. Ya-Kun Cao, et al. Microinjection of urotensin II into the rostral ventrolateral medulla increases sympathetic vasomotor tone via the GPR14/ERK pathway in rats. Hypertens Res. 2020 Aug;43(8):765-771.

Chemical & Physical Properties

[ Density]:
1.71

[ Molecular Formula ]:
C₁₂₀H₁₈₂N₃₈O₄₃S₆

[ Molecular Weight ]:
3037.35000

[ Exact Mass ]:
3035.15000

[ PSA ]:
1496.38000

[ Storage condition ]:
−20°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
UN 3172

[ WGK Germany ]:
3

[ RTECS ]:
GL2665050

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

Differential blockade of rat alpha3beta4 and alpha7 neuronal nicotinic receptors by omega-conotoxin MVIIC, omega-conotoxin GVIA and diltiazem.

Br. J. Pharmacol. 127 , 1375, (1999)

Rat alpha3beta4 or alpha7 neuronal nicotinic acetylcholine receptors (AChRs) were expressed in Xenopus laevis oocytes, and the effects of various toxins and non-toxin Ca2+ channel blockers studied. Ni...

Spermine does not compete with omega-conotoxin GVIA in the striatum radiatum of the hippocampal slice.

Brain Res. 772 , 191, (1997)

The effect of spermine (Spm) and of omega-conotoxin GVIA (CTX) on the population excitatory postsynaptic potentials (pEPSP) in stratum radiatum of the CA1 area were compared. CTX decreased irreversibl...