D-Boc valine methyl ester

Names

[ Name ]:
D-Boc valine methyl ester

[Synonym ]:
N-tert-Butoxycarbonyl-D-valine methyl ester
Methyl N-{[(2-Methyl-2-Propanyl)Oxy]Carbonyl}-D-Valinate
Boc-D-Val-OMe

Biological Activity

[Description]:

D-Boc Valine methyl ester is an intermediate in the synthesis of Taltobulin (HY-15584). Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.

Chemical & Physical Properties

[ Density]:
1.02g/cm3

[ Boiling Point ]:
306.042°C at 760 mmHg

[ Molecular Formula ]:
C₁₁H₂₁NO₄

[ Molecular Weight ]:
231.28900

[ Flash Point ]:
138.889°C

[ Exact Mass ]:
231.14700

[ PSA ]:
64.63000

[ LogP ]:
2.09960

[ Index of Refraction ]:
1.442

Safety Information

[ HS Code ]:
2924199090

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%