4-(2-(PROPYLAMINO)ETHYL)INDOLIN-2-ONE

Names

[ Name ]:
4-(2-(PROPYLAMINO)ETHYL)INDOLIN-2-ONE

[Synonym ]:
2H-Indol-2-one, 1,3-dihydro-4-[2-(propylamino)ethyl]-
4-[2-(propylamino)ethyl]-1,3-dihydroindol-2-one
4-[2-(Propylamino)ethyl]-1,3-dihydro-2H-indol-2-one
4-(2-(Propylamino)ethyl)indolin-2-one

Biological Activity

[Description]:

N-Despropyl Ropinirole (SKF-104557) is an active metabolite of the dopamine D2 receptor agonist Ropinirole (HY-B0623). N-Despropyl Ropinirole is a full agonist at human D2 and D3 receptors. N-Despropyl Ropinirole is a partial agonistof the hD4 receptor[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Coldwell MC, et al. Comparison of the functional potencies of ropinirole and other dopamine receptor agonists at human D2(long), D3 and D4.4 receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1999 Aug;127(7):1696-702.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
387.7±42.0 °C at 760 mmHg

[ Melting Point ]:
260-265ºC

[ Molecular Formula ]:
C₁₃H₁₈N₂O

[ Molecular Weight ]:
218.29

[ Flash Point ]:
154.2±28.0 °C

[ Exact Mass ]:
218.141907

[ PSA ]:
41.13000

[ LogP ]:
1.59

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.549

Safety Information

[ HS Code ]:
2933790090

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%