Angoline hydrochloride

Names

[ Name ]:
Angoline hydrochloride

Biological Activity

[Description]:

Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].

[Related Catalog]:

Signaling Pathways >> Stem Cell/Wnt >> STAT

Research Areas >> Cancer

Signaling Pathways >> JAK/STAT Signaling >> STAT

[Target]

IC50: 11.56 μM (IL6/STAT3 signaling pathway)

[References]

[1]. Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₂ClNO₅

[ Molecular Weight ]:
415.87

Safety Information

[ Hazard Codes ]:
Xi

Angoline hydrochloride

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Related Compounds