Hexaethylene glycol dimethyl ether

Names

[ Name ]:
Hexaethylene glycol dimethyl ether

[Synonym ]:
1,17-Dimethoxy-3,6,9,12,15-pentaoxa-heptadecan
2,5,8,11,14,17,20-heptaoxahenicosane
Hexaaethylenglykol-dimethylaether
2,5,8,11,14,17,20-Heptaoxaheneicosane
O,O'-Dimethyl-hexaaethylenglykol
Hexaethylene glycol dimethyl ether
1,17-dimethoxy-3,6,9,12,15-pentaoxa-heptadecane
EINECS 214-006-8

Biological Activity

[Description]:

Hexaethylene glycol dimethyl ether is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.02g/cm3

[ Boiling Point ]:
359ºC at 760mmHg

[ Molecular Formula ]:
C₁₄H₃₀O₇

[ Molecular Weight ]:
310.38400

[ Flash Point ]:
136.5ºC

[ Exact Mass ]:
310.19900

[ PSA ]:
64.61000

[ LogP ]:
0.36220

[ Vapour Pressure ]:
5.08E-05mmHg at 25°C

[ Index of Refraction ]:
1.433

Safety Information

[ HS Code ]:
2901100000

Customs

[ HS Code ]: 2901100000

[ Summary ]:
2901100000 saturated acyclic hydrocarbons。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:2.0%。General tariff:30.0%