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Lintopride

Names

[ CAS No. ]:
107429-63-0

[ Name ]:
Lintopride

[Synonym ]:
UNII-C2R0GEU722
Lintopridum [INN-Latin]
Lintoprida [INN-Spanish]
Lintopridum
Lintoprida
Lintopride

Biological Activity

[Description]:

Lintopride is a 5HT4 antagonist with moderate 5HT3 antagonist properties.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor
Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
Research Areas >> Neurological Disease

[Target]

5HT4[1]


[In Vitro]

Lintopride significantly increases the lower oesophageal sphincter basal tone without affecting lower oesophageal sphincter physiological relaxation after swallowing. Peristaltic waves are also enhanced by Lintopride[1].

[References]

[1]. Delvaux M, et al. The effects of lintopride, a 5HT-4 antagonist, on oesophageal motility. Aliment Pharmacol Ther. 1995 Oct;9(5):563-9.


[Related Small Molecules]

Harmine | Pimavanserin | Serotonin hydrochloride | Sodium Ferulate | Thioridazine hydrochloride | Brexpiprazole | Risperidone | TG6-10-1 | Cariprazine | Quetiapine | SERTINDOLE | Alprenolol hydrochloride | B-HT 920 | Ketanserin | Palonosetron hydrochloride

Chemical & Physical Properties

[ Density]:
1.35g/cm3

[ Boiling Point ]:
494.1ºC at 760 mmHg

[ Molecular Formula ]:
C14H19ClN4O2

[ Molecular Weight ]:
310.77900

[ Flash Point ]:
252.6ºC

[ Exact Mass ]:
310.12000

[ PSA ]:
83.44000

[ LogP ]:
1.92410

[ Vapour Pressure ]:
6.62E-10mmHg at 25°C

[ Index of Refraction ]:
1.618

[ Storage condition ]:
2-8℃


Related Compounds