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CD 1530

Names

[ CAS No. ]:
107430-66-0

[ Name ]:
CD 1530

[Synonym ]:
cd 1530

Biological Activity

[Description]:

CD1530 is a selective RARγ agonist with an Kd of 150 nM[1]. CD1530 has been used in combination with bexarotene to inhibit oral carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide in a mouse model of human oral-cavity and esophageal squamous-cell carcinoma[2].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Metabolic Enzyme/Protease >> RAR/RXR

[Target]

RARγ:150 nM (Kd)


[References]

[1]. Bernard BA, et al. Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma. Biochem Biophys Res Commun. 1992 Jul 31;186(2):977-83.

[2]. Tang XH, et al. Combination of bexarotene and the retinoid CD1530 reduces murine oral-cavity carcinogenesis induced by the carcinogen 4-nitroquinoline 1-oxide. Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8907-12.

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Boiling Point ]:
610.7ºC at 760 mmHg

[ Molecular Formula ]:
C27H26O3

[ Molecular Weight ]:
398.49400

[ Flash Point ]:
337.2ºC

[ Exact Mass ]:
398.18800

[ PSA ]:
57.53000

[ LogP ]:
6.37840

[ Vapour Pressure ]:
9.03E-16mmHg at 25°C

[ Index of Refraction ]:
1.688

Related Compounds